A developmentally delayed 40 year old man named Shonzi is sent to live with his brother Todd. But when Shonzi develops a crush on Todd's new girlfriend Lindsay, he threatens to reveal past secrets that could ultimately tear the couple apart.

《104号房间》背景设定在一个平均水准酒店中的104号房间，剧集将讲述每集该房间的不同房客，他们形形色色的故事。